AustralieFrV1, Main, Exploration, bibRecord, 008433

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Identifieur interne : 008433 ( Main/Exploration ); précédent : 008432; suivant : 008434

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Auteurs : Michele Baccarani [Italie, Royaume-Uni, Espagne, Suisse, France, États-Unis, Australie, Suède, Allemagne] ; Jorge Cortes ; Fabrizio Pane ; Dietger Niederwieser ; Giuseppe Saglio ; Jane Apperley ; Francisco Cervantes ; Michael Deininger ; Alois Gratwohl ; François Guilhot ; Andreas Hochhaus ; Mary Horowitz ; Timothy Hughes ; Hagop Kantarjian ; Richard Larson ; Jerald Radich ; Bengt Simonsson ; Richard T. Silver ; John Goldman ; Rudiger Hehlmann

Source :

Journal of clinical oncology [ 0732-183X ] ; 2009.

RBID : Pascal:10-0036534

Descripteurs français

Pascal (Inist)
- Leucémie myéloïde chronique, Conduite à tenir, Recommandation, Europe, Cancérologie.
Wicri :
- topic : Recommandation.

English descriptors

KwdEn :
- Cancerology, Chronic myelogenous leukemia, Clinical management, Europe, Recommendation.

Abstract

Purpose To review and update the European LeukemiaNet (ELN) recommendations for the management of chronic myeloid leukemia with imatinib and second-generation tyrosine kinase inhibitors (TKls), including monitoring, response definition, and first- and second-line therapy. Methods These recommendations are based on a critical and comprehensive review of the relevant papers up to February 2009 and the results of four consensus conferences held by the panel of experts appointed by ELN in 2008. Results Cytogenetic monitoring was required at 3, 6, 12, and 18 months. Molecular monitoring was required every 3 months. On the basis of the degree and the timing of hematologic, cytogenetic, and molecular results, the response to first-line imatinib was defined as optimal, suboptimal, or failure, and the response to second-generation TKIs was defined as suboptimal or failure. Conclusion Initial treatment was confirmed as imatinib 400 mg daily. Imatinib should be continued indefinitely in optimal responders. Suboptimal responders may continue on imatinb, at the same or higher dose, or may be eligible for investigational therapy with second-generation TKls. In instances of imatinib failure, second-generation TKls are recommended, followed by allogeneic hematopoietic stem-cell transplantation only in instances of failure and, sometimes, suboptimal response, depending on transplantation risk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979100

Affiliations:

Allemagne, Australie, Espagne, France, Italie, Royaume-Uni, Suisse, Suède, États-Unis
Angleterre, Bade-Wurtemberg, Catalogne, District de Karlsruhe, District de Leipzig, Grand Londres, Nouvelle-Aquitaine, Piémont, Poitou-Charentes, Saxe (Land)
Barcelone, Leipzig, Londres, Mannheim, Poitiers, Turin

Le document en format XML

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<author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name>
</author>
<author><name sortKey="Deininger, Michael" sort="Deininger, Michael" uniqKey="Deininger M" first="Michael" last="Deininger">Michael Deininger</name>
</author>
<author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name>
</author>
<author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name>
</author>
<author><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name>
</author>
<author><name sortKey="Horowitz, Mary" sort="Horowitz, Mary" uniqKey="Horowitz M" first="Mary" last="Horowitz">Mary Horowitz</name>
</author>
<author><name sortKey="Hughes, Timothy" sort="Hughes, Timothy" uniqKey="Hughes T" first="Timothy" last="Hughes">Timothy Hughes</name>
</author>
<author><name sortKey="Kantarjian, Hagop" sort="Kantarjian, Hagop" uniqKey="Kantarjian H" first="Hagop" last="Kantarjian">Hagop Kantarjian</name>
</author>
<author><name sortKey="Larson, Richard" sort="Larson, Richard" uniqKey="Larson R" first="Richard" last="Larson">Richard Larson</name>
</author>
<author><name sortKey="Radich, Jerald" sort="Radich, Jerald" uniqKey="Radich J" first="Jerald" last="Radich">Jerald Radich</name>
</author>
<author><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name>
</author>
<author><name sortKey="Silver, Richard T" sort="Silver, Richard T" uniqKey="Silver R" first="Richard T." last="Silver">Richard T. Silver</name>
</author>
<author><name sortKey="Goldman, John" sort="Goldman, John" uniqKey="Goldman J" first="John" last="Goldman">John Goldman</name>
</author>
<author><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rudiger" last="Hehlmann">Rudiger Hehlmann</name>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical oncology</title>
<title level="j" type="abbreviated">J. clin. oncol.</title>
<idno type="ISSN">0732-183X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term>
<term>Chronic myelogenous leukemia</term>
<term>Clinical management</term>
<term>Europe</term>
<term>Recommendation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Leucémie myéloïde chronique</term>
<term>Conduite à tenir</term>
<term>Recommandation</term>
<term>Europe</term>
<term>Cancérologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Recommandation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose To review and update the European LeukemiaNet (ELN) recommendations for the management of chronic myeloid leukemia with imatinib and second-generation tyrosine kinase inhibitors (TKls), including monitoring, response definition, and first- and second-line therapy. Methods These recommendations are based on a critical and comprehensive review of the relevant papers up to February 2009 and the results of four consensus conferences held by the panel of experts appointed by ELN in 2008. Results Cytogenetic monitoring was required at 3, 6, 12, and 18 months. Molecular monitoring was required every 3 months. On the basis of the degree and the timing of hematologic, cytogenetic, and molecular results, the response to first-line imatinib was defined as optimal, suboptimal, or failure, and the response to second-generation TKIs was defined as suboptimal or failure. Conclusion Initial treatment was confirmed as imatinib 400 mg daily. Imatinib should be continued indefinitely in optimal responders. Suboptimal responders may continue on imatinb, at the same or higher dose, or may be eligible for investigational therapy with second-generation TKls. In instances of imatinib failure, second-generation TKls are recommended, followed by allogeneic hematopoietic stem-cell transplantation only in instances of failure and, sometimes, suboptimal response, depending on transplantation risk.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>Catalogne</li>
<li>District de Karlsruhe</li>
<li>District de Leipzig</li>
<li>Grand Londres</li>
<li>Nouvelle-Aquitaine</li>
<li>Piémont</li>
<li>Poitou-Charentes</li>
<li>Saxe (Land)</li>
</region>
<settlement><li>Barcelone</li>
<li>Leipzig</li>
<li>Londres</li>
<li>Mannheim</li>
<li>Poitiers</li>
<li>Turin</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Apperley, Jane" sort="Apperley, Jane" uniqKey="Apperley J" first="Jane" last="Apperley">Jane Apperley</name>
<name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name>
<name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name>
<name sortKey="Deininger, Michael" sort="Deininger, Michael" uniqKey="Deininger M" first="Michael" last="Deininger">Michael Deininger</name>
<name sortKey="Goldman, John" sort="Goldman, John" uniqKey="Goldman J" first="John" last="Goldman">John Goldman</name>
<name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name>
<name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name>
<name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rudiger" last="Hehlmann">Rudiger Hehlmann</name>
<name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name>
<name sortKey="Horowitz, Mary" sort="Horowitz, Mary" uniqKey="Horowitz M" first="Mary" last="Horowitz">Mary Horowitz</name>
<name sortKey="Hughes, Timothy" sort="Hughes, Timothy" uniqKey="Hughes T" first="Timothy" last="Hughes">Timothy Hughes</name>
<name sortKey="Kantarjian, Hagop" sort="Kantarjian, Hagop" uniqKey="Kantarjian H" first="Hagop" last="Kantarjian">Hagop Kantarjian</name>
<name sortKey="Larson, Richard" sort="Larson, Richard" uniqKey="Larson R" first="Richard" last="Larson">Richard Larson</name>
<name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name>
<name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name>
<name sortKey="Radich, Jerald" sort="Radich, Jerald" uniqKey="Radich J" first="Jerald" last="Radich">Jerald Radich</name>
<name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name>
<name sortKey="Silver, Richard T" sort="Silver, Richard T" uniqKey="Silver R" first="Richard T." last="Silver">Richard T. Silver</name>
<name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</noRegion>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</region>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</region>
</country>
<country name="Suisse"><noRegion><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</noRegion>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</region>
</country>
<country name="États-Unis"><noRegion><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</noRegion>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</country>
<country name="Australie"><noRegion><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</noRegion>
</country>
<country name="Suède"><noRegion><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</region>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
<name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name>
</country>
</tree>
</affiliations>
</record>

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Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

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